The Editors' Choice

Atopic dermatitis (AD) is associated with intense itch and loss of sleep in early life and with food allergy and asthma, in later life. The early origins of AD are incompletely understood but involve a complex interplay between the skin barrier, immune dysregulation, and the cutaneous microbiome. Eczema has a close relationship with Staphylococcus aureus colonization, which is associated with flares of AD. However, it was not known whether S aureus colonization preceded eczema or eczema followed S aureus colonization.

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