Investigation of IGF2, IGFBP2 and p63 proteins in rhabdomyosarcoma tumors.

Investigation of IGF2, IGFBP2 and p63 proteins in rhabdomyosarcoma tumors.

Growth Horm IGF Res. 2017 Jan 13;33:17-22

Authors: Yu Y, Fu L, Wang S, Jin Y, Han S, Chu P, Lu J, Guo Y, He L, Ni X

Abstract
Many efforts have been made to address involvement of the insulin-like growth-factor (IGF) pathway in rhabdomyosarcoma (RMS) pathogenesis, but the actual role of IGF in RMS is still controversial.
OBJECTIVE: To investigate the implications of IGF2, IGFBP2 and p63 in RMS, and further explored their potential interaction.
DESIGN: A total of 114 specimens of RMS along with clinic-pathologic characteristics were collected from the year of 2003 to 2013. Protein abundance was detected by immunohistochemical staining, potential relationships between protein levels and clinic-pathological parameters were applied using correlation analysis.
RESULTS: The results showed positive correlation between IGFBP2 and p63 (r=0.271, p=0.003), suggesting that the interaction of IGFBP2 and p63 might account for the pathogenesis of RMS. In the subtype analysis, positive correlation was still found in embryonal rhabdomyosarcoma (ERMS, r=0.214, p=0.034) and alveolar rhabdomyosarcoma (ARMS, r=0.498, p=0.048). By focusing on the interaction of IGF pathway and p63, our results reveal additional signs to elucidate difference of pathogenesis and severity between ERMS and ARMS.
CONCLUSIONS: The present study provides novel evidence to elucidate RMS pathogenesis and may be beneficial to clinical diagnosis and therapy for RMS.

PMID: 28129571 [PubMed - as supplied by publisher]

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