Cancer is a major health burden worldwide. Despite the advances in our understanding of its pathogenesis and continued improvement in cancer management and outcomes, there remains a strong clinical demand for more accurate and reliable biomarkers of metastatic progression and novel therapeutic targets to abrogate angiogenesis and tumour progression. Aquaporin 1 (AQP1) is a small hydrophobic integral transmembrane protein with a predominant role in trans-cellular water transport. Recently, over-expression of AQP1 has been associated with many types of cancer as a distinctive clinical prognostic factor. This has prompted researchers to evaluate the link between AQP1 and cancer biological functions. Available literature implicates the role of AQP1 in tumour cell migration, invasion and angiogenesis. This article reviews the current understanding of AQP1-facilitated tumour development and progression with a focus on regulatory mechanisms and downstream signalling pathways.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2k5jlzj
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Astrophel' is a fanciful half-Greek anagram for the poet's own name, and Stella (Star) designates Lady Penelope Devereux, who at abo...
-
is and in to a was not you i of it the be he his but for are this that by on at they with which she or from had we will have an what been on...
-
The impact of industrialised societies on Earth has been described in a mathematical formula that should scare us all, says Owen Gaffney ...
-
Bumblebees have shown they can learn how to push a ball into a hole to get a reward, staking their claim to be considered tool users from ...
-
Abstract Combating gliomagenic global immunosuppression is the one of the emerging key for improving prognosis in malignant glioma. Apopt...
-
Publication date: February 2017 Source: Cryobiology, Volume 74 Author(s): Reza Masoudi, Ahmad Zare Shahneh, Armin Towhidi, Hamid Kohram, A...
-
by Huiyuan Zhu, Lian Zhang, Yali Wang, Preeti Hamal, Xiaofang You, Haixia Mao, Fei Li, Xiwen Sun The aim of this study was to assess whethe...
-
Abstract: Patients with neurofibromatosis type 1 (NF-1) have a well-known predisposition for certain types of malignancies, including lympho...
-
Party Themes and Group Games You Sent In! These ideas sound like a lot of fun for everyone. You are sure to find some new ideas and inspirat...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου