Epigenetics of Epithelial-to-Mesenchymal-Transition in pancreatic carcinoma

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases with late diagnosis, rapid progression, high invasiveness and early metastasis. Epithelial-to-mesenchymal-transition (EMT) is a crucial step in metastasis that enables polarized immotile epithelial cells to gain fibroblast-like mesenchymal abilities such as enhanced motility. The dynamic process of EMT in PDAC with its powerful influence on disease progression and especially metastasis is of vigorous interest in biomedical research to elucidate its signaling pathways and regulation mechanisms. It is evident that epigenetics like histone and DNA modification or non-coding RNAs like microRNAs (miRs) and long non-coding RNAs (lncRNAs) are of high importance in initiation and progress of EMT in PDAC. This review analyzes the latest research dealing with EMT and its epigenetic regulation in PDAC and summarizes its potentials in diagnostic, prognostic and therapeutic management. This article is protected by copyright. All rights reserved.

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