A novel neoadjuvant therapy for operable locally-invasive Non-Small Cell Lung Cancer (NSCLC). Phase I study of neo-adjuvant Stereotactic Body RadioTherapy (SBRT). LINNEARRE I (NCT02433574)

Despite improved staging and operative techniques, the rate of incomplete resection (R1) of non-small cell lung cancer (NSCLC) remains essentially unchanged. Patients with R1 resection have worse survival compared to those with complete resection (R0). Stereotactic body radiotherapy (SBRT) is a rapid and convenient radiotherapy treatment that delivers high dose radiotherapy to tumors with high precision while sparing normal organs. Although its efficacy in treating small lung tumors is documented, its use as neoadjuvant therapy for locally advanced (LA) NSCLC has not been examined.

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