Τρίτη 31 Ιανουαρίου 2017

Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells [Immunology and Inflammation]

Mice deficient in the transcriptional repressor B-cell CLL/lymphoma 6 (Bcl6) exhibit similar T helper 2 (TH2) immune responses as patients with allergic diseases. However, the molecular mechanisms underlying Bcl6-directed regulation of TH2 cytokine genes remain unclear. We identified multiple Bcl6/STAT binding sites (BSs) in TH2 cytokine gene loci. We found...

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