<span class="paragraphSection"><div class="boxTitle">Abstract</div>To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuV<sup>JL5</sup>), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the background of a recombinant JL5 genome (rMuV<sup>JL5</sup>). Cross-reactivity and cross-neutralization between this chimeric recombinant MuV bearing the F and HN glycoproteins of BMV (rMuV<sup>JL5</sup>-F/HN<sup>BMV</sup>) virus and rMuV<sup>JL5</sup> were demonstrated using hyperimmune mouse serum samples and a curated panel of human serum. All mouse and human serum samples that were able to neutralize rMuV<sup>JL5</sup> infection had cross-neutralizing activity against rMuV<sup>JL5</sup>-F/HN<sup>BMV</sup>. Our data suggest that persons who have neutralizing antibodies against MuV might be protected from infection by BMV.</span>
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