Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats

<span class="paragraphSection"><div class="boxTitle">Abstract</div>To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuV^JL5), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the background of a recombinant JL5 genome (rMuV^JL5). Cross-reactivity and cross-neutralization between this chimeric recombinant MuV bearing the F and HN glycoproteins of BMV (rMuV^JL5-F/HN^BMV) virus and rMuV^JL5 were demonstrated using hyperimmune mouse serum samples and a curated panel of human serum. All mouse and human serum samples that were able to neutralize rMuV^JL5 infection had cross-neutralizing activity against rMuV^JL5-F/HN^BMV. Our data suggest that persons who have neutralizing antibodies against MuV might be protected from infection by BMV.</span>

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