Anti-diabetic activity of Garcinia xanthochymus seeds

Abstract

In the present study, extracts of Garcinia xanthochymus seeds were used to determine anti-diabetic, anti-oxidant, and biochemical activities in alloxan-induced diabetic mice. Of the petroleum ether (G. xanthochymus petroleum ether extract (GXSPE)) and methanol (G. xanthochymus methanol extract (GXSME)) seed extracts, 100 and 200 mg/kg were used and compared with normal, diabetic, and glibenclamide groups for various activities. The parameters like blood glucose, body weight, serum biochemicals, serum enzymes, and anti-oxidative enzymes in different groups were monitored at regular intervals. The extracts produced a dose-dependent response for blood glucose levels and associated serum biochemicals, serum enzymes, and anti-oxidative enzymes compared to the diabetic control groups. The high-pressure liquid chromatography (HPLC) analysis revealed the presence of phenolic compounds especially gallic acid, 4-hydroxybenzoic acid, and tannic acid, which have an important role in anti-diabetic action. Thus, this study points out the strong anti-diabetic, anti-oxidant, and biochemical activity of G. xanthochymus seeds. Hence, it can be used for the development of an effective herbal pharmaceutical drug for curing diabetes.

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