Phosphoprotein is the main co-factor of the viral RNA polymerase of Mononegavirales. It is involved in multiple interactions that are essential for the polymerase function. Most prominently it positions the polymerase complex onto the nucleocapsid, but also acts as a chaperone for the nucleoprotein. Mononegavirales phosphoproteins lack sequence conservation, but contain all large disordered regions. We show here that N-and C-terminal intrinsically disordered regions account for 80% of the phosphoprotein of the Respiratory Syncytial Virus. But these regions display marked dynamic heterogeneity. Whereas almost stable helices are formed C-terminally to the oligomerization domain, extremely transient helices are present in the N-terminal region. They all mediate internal long-range contacts in this non-globular protein. Transient secondary elements together with fully disordered regions also provide protein binding sites recognized by the Respiratory Syncytial Virus nucleoprotein and compatible with weak interactions required for the processivity of the polymerase.
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