Increasing circulating exosomes-carrying TRPC5 predicts chemoresistance in metastatic breast cancer patients

Summary

Chemoresistance, the major obstacle in breast cancer chemotherapy, results in unnecessary chemotherapy and wasting of medical resources. Up to now, no feasible method is available to predict chemoresistance before chemotherapy. In our previously study, elevated expression of transient receptor potential channel TRPC5 was found as an essential element for chemoresistance in breast cancer cells, and could be transferred to chemosensitive breast cancer cells through releasing extracellular vesicles (EVs)-containing TRPC5 from chemoresistant cells, resulting in acquired chemoresistance. Exosomes, a type of EVs, are secreted membrane enclosed vesicles of 50–150 nm diameter. In this study we found that circulating exosomes in peripheral blood from breast cancer patients carried TRPC5. Circulating exosome-carrying TRPC5 (cirExo-TRPC5) level was significantly correlated with TRPC5 expression level in breast cancer tissues and tumor response to chemotherapy. Furthermore, increased cirExo-TRPC5 level after chemotherapy was preceding progressive disease (PD) based on imaging examination and strongly predicted acquired chemoresistance. Taken together, our study demonstrated that cirExo-TRPC5 might act as a noninvasive chemoresistance marker and might serve as an adjuvant to the current imaging examination-based chemoresistance.

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