Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

Publication date: 3 November 2016
Source:Cell, Volume 167, Issue 4
Author(s): J. Tiago Gonçalves, Simon T. Schafer, Fred H. Gage
The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the molecular machinery involved in the generation of new neurons from a pool of adult neural stem cells and their integration into functional hippocampal circuits. We also summarize the potential functions of these newborn neurons in the adult brain, their contribution to behavior, and their relevance to disease.

Teaser

The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. Understanding the molecular mechanisms underlying the generation, integration, and functions of these newborn neurons in the adult brain may help design future regenerative approaches for treating neurological disease.


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