Chronic Subclinical Inflammation in Middle Aged Bangladeshi Population: Association with Low High-density Lipoprotein Cholesterol

2016-10-27T16-00-40Z
Source: Journal of Molecular Pathophysiology
Mohammad Abdul Hai Siddique, Muhammad Saiedullah, Matiar Rahman, Liaquat Ali, Mohammad Amirul Islam.
Aim: The present study was undertaken to investigate the association of chronic subclinical inflammation as assessed by high sensitivity C-reactive protein (hsCRP) with high-density lipoprotein (HDL) cholesterol in a middle aged Bangladeshi population. Materials and Methods: Total 348 adults (169 male, 179 female) were included and anthropometric data and clinical histories were recorded. Serum lipids were measured by enzymatic endpoint technique and hsCRP was estimated by immunoturbidimetric method. Results: The mean of age and body mass index (BMI) of the total subjects were 50.5 ± 11.5 years and 26.7 ± 4.5 kg/m2 respectively. Substantial proportions (57.47%) of the subjects had low HDL cholesterol. Of the total subjects, 45.4% had hsCRP > 3.0 mg/l followed by 31.9% with hsCRP: 1.0-3.0 mg/l coupled with elevation of one or more traditional risk factors of CVDs. Lipid parameters showed no significant difference between subjects with low and moderate (hsCRP ≤3.0 mg/l) and high hsCRP (hsCRP > 3.0 mg/l). But BMI was significantly higher in high hsCRP group compared to low hsCRP group [25.4 (23.3-27.9) vs 27.3 (24.3-30.1) kg/m2, p


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