Antidiabetic and antioxidant effects of Croton lobatus l. in alloxan-induced diabetic rats

2016-09-25T14-22-59Z
Source: Journal of Intercultural Ethnopharmacology
Taiye Remi Fasola, Blessing Ukwenya, Ademola Adetkunbo Oyagbemi, Temidayo Olutayo Omobowale, Temitayo Olabisi Ajibade.
Background: Croton lobatus contains high amount of antioxidant phytochemicals that probably account for its wide use as food and medicine in the traditional communities of West Africa. Methods: The study evaluated the modulatory role of methanol extract of Croton lobatus leaf on alloxan-induced diabetes and associated cardiovascular complications in male rats randomly selected and assigned to one of six groups (A to F) of eight animals each: A (distilled water); B (corn oil); C (Alloxan); D (Alloxan + 100 mg kg-1 Croton lobatus); E: (Alloxan + 200 mg kg-1 C. lobatus); and F (Alloxan + 100 mg kg-1 glibenclamide). The extract was administered orally for 14 days. Results: Acute toxicity studies revealed no mortality of rats at with the administration of different doses of extract up to the 5,000 mg kg-1 dose. Diabetic rats treated with 100 and 200 mg kg-1 C. lobatus leaf extract had significant (p

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