Effects of Standing and Light-Intensity Walking and Cycling on 24-h Glucose.

Effects of Standing and Light-Intensity Walking and Cycling on 24-h Glucose.

Med Sci Sports Exerc. 2016 Jul 27;

Authors: Crespo NC, Mullane SL, Zeigler ZS, Buman MP, Gaesser GA

Abstract
PURPOSE: To compare 24-h and postprandial glucose responses to incremental intervals of standing (STAND), walking (WALK) and cycling (CYCLE) to a sit-only (SIT) condition.
METHODS: Nine overweight/obese (BMI= 29 ± 3 kgm) adults (30 ± 15 yr) participated in this randomized crossover full-factorial study, with each condition performed 1 wk apart. STAND, CYCLE and WALK intervals increased from 10 minh to 30 minh (2.5 h total) during an 8-h workday. WALK (1.0 mileh) and STAND were matched for upright time, and WALK and CYCLE were matched for energy expenditure (~2 METs). Continuous interstitial glucose monitoring was performed for 24 h to include the 8-h workday (LAB), after-work evening hours (EVE), and sleep (SLEEP). Three 2-h postprandial periods were also analyzed. Linear mixed models were used to test for condition differences.
RESULTS: Compared to SIT (5.7 ± 1.0 mmolL), mean 24-h glucose during STAND (5.4 ± 0.9 mmolL) and WALK (5.3 ± 0.9 mmolL) were lower, and CYCLE (5.1 ± 1.0 mmolL) was lower than all other conditions (all P<0.001). During LAB and EVE, mean glucose was lower for STAND, WALK, and CYCLE compared to SIT (P<0.001). During SLEEP, mean glucose for CYCLE was lower than all other conditions (P<0.001). Compared to SIT, cumulative 6-h postprandial mean glucose was 5-12% lower (P<0.001) during STAND, WALK and CYCLE, and 6-h postprandial glucose integrated area under the curve was 24% during WALK (P<0.05) and 44% lower during CYCLE (P<0.001).
CONCLUSIONS: Replacing sitting with regular intervals of standing or light-intensity activity during an 8-h workday reduces 24-h and postprandial glucose. These effects persist during evening hours, with CYCLE having the largest and most sustained effect.

PMID: 27471786 [PubMed - as supplied by publisher]

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