Phyllodium pulchellum (P. pulchellum) is a folk medicine with a significant number of bioactivities. The aim of this study was to investigate the effects displayed by alkaloids fractions, isolated from the roots of P. pulchellum, on neurotransmitters monoamine levels and on monoamine oxidase (MAO) activity. Six alkaloids, which had indolealkylamine or β-carboline skeleton, were obtained by chromatographic technologies and identified by spectroscopic methods such as NMR and MS. After treatment with alkaloids of P. pulchellum, the reduction of DA levels (54.55%) and 5-HT levels (35.01%) in rat brain was observed by HPLC-FLD. The effect of alkaloids on the monoamines metabolism was mainly related to MAO inhibition, characterized by IC50 values of and μg/mL for MAO-A and MAO-B, respectively. The acute toxicity indicated that P. pulchellum extract was nontoxic.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XEii66
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Logical Problem of Evil. The existence of evil and suffering in our world seems to pose a serious challenge to belief in the existence of a ...
-
BABYLON Floral Denver CO - Unique Original cutting edge floral design. Order now for Mother's Day. We deliver fresh flowers, green and b...
-
Abstract To measure integral doses in image-guided radiation therapy, we developed an integral condenser dosimeter comprising a disposable...
-
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader https://ift.tt/2ErcmxL via IFTTT
-
Argumentative Essay Topics. Looking for a topic you can properly research? To find a good theme is a serious but important task. An argument...
-
Abstract Determining the cause of unexplained death in all age groups, including infants, is a priority in forensic medicine. The triple r...
-
Browse Essays By Theme. Use this feature to browse through the tens of thousands of essays that have been submitted to This I Believe. Selec...
-
Patients who undergo endovascular repair of aortic aneurysms (EVAR) require life-long surveillance because complications including, in parti...
-
Trigonometry & Calculus - powered by WebMath Click here for K-12 lesson plans, family activities, virtual labs and more! from #Alexand...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου