IgE and FcεRI are highly expressed on innate cells in psoriasis

Abstract

Background

Although elevated serum IgE levels have been reported in psoriasis, the role of IgE in psoriasis still needs to be clarified.

Objective

To analyze serum total IgE levels as well as the presence and distributionof IgE and FcεRI in psoriatic lesions, and investigate alteration of IgE and FcεRI after successful systemic treatment.

Methods

Total serum IgE levels was determined using ELISA. The expression and localization of IgE and FcεRI was investigated using immunohistochemistry and double-immunofluorescence.

Results

Elevated total serum IgE levels were found in 39% patients with psoriasis. The levels of total serum IgE were significantly higher in male patients compared to females. Furthermore, total serum IgE levels decreased after successful systemic treatment. A positive correlation between IgE+ and FcεRI + cells and a significant increase of these cells was found in psoriatic lesions as compared to normal skin. Interestingly, IgE+ and FcƐRI + cells decreased significantly after successful therapy with ustekinumab. IgE and FcεRI were co-expressed on mast cells, epidermal Langerhans cells, dermal DCs, macrophages and a few neutrophils.

Conclusions

IgE might participate in the development of psoriasis by activating FcεRI-bearing cells.

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