The effect of ovariectomy and two antiresorptive therapeutic agents on bone response in rats: a three-dimensional imaging analysis

Publication date: Available online 13 April 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Priscilla Coutinho Romualdo, Nayane Barbosa Fernandes Furlanetto Cunha, Graziela Bianchi Leoni, Manoel Damião de Sousa-Neto, Alberto Consolaro, Alexandra Mussolino de Queiroz, Raquel Assed Bezerra da Silva, Lea Assed Bezerra da Silva, Paulo Nelson-Filho
ObjectiveTo evaluate bone mineral density (BMD) and microarchitecture in femurs and maxillary bones of ovariectomized (OVX) rats treated or not treated with alendronate (ALD) or odanacatib (ODN).Study Design: Twenty rats were divided into groups: SHAM, OVX, OVX/ALD and OVX/ODN. After 12 weeks, the femurs and maxillae were removed and subjected to three-dimensional analysis by microcomputed tomography. Results were analyzed with one-way ANOVA and Tukey's test (α=0.05).ResultsOVX decreased maxillary and femoral BMD and altered femoral microarchitecture (p<0.05). The drugs increased BMD of both types of bones, but only ALD maintained the phenotype similar to the sham group. The action of ALD was limited to the femoral Tb.Sp (trabecular separation). OVX and the drugs had no effect on the microarchitecture of the maxilla (p>0.05).ConclusionsAlendronate and odanacatib therapy increased BMD in both bones after ovariectomy. Alendronate was more successful than odanacatip in preserving the morphology of bone similar to the sham group. ALD maintained the phenotype for Tb.Sp in the femur but ODN did not. In the maxillae, neither ovariectomy nor either antiresorptive drug had significant effects on microarchitecture.



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