Abdominal manifestations of IgG4-related disease: a pictorial review

Abstract

In the last decade, autoimmune pancreatitis has become recognised as part of a wider spectrum of IgG4-related disease, typically associated with elevated serum IgG4 levels and demonstrating a response to corticosteroid therapy. Radiologically, there is imaging overlap with other benign and neoplastic conditions. This pictorial review discusses the intra-abdominal manifestations of this disease on cross-sectional imaging before and after steroid treatment and the main radiological features which help to distinguish it from other key differentials.

Teaching Points

• Autoimmune pancreatitis is part of a spectrum of IgG4-related disease.

• Diagnosis is based on raised serum IgG4, clinical, radiological and histopathological findings.

• Cross-sectional imaging can demonstrate the typical findings of abdominal IgG4-related disease.

• Cross-sectional imaging can be used to monitor response to corticosteroid treatment.

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