Vitamin D deficiency and periodontal clinical attachment loss in HIV seropositive women: a secondary analysis conducted in the women's interagency HIV study (WIHS)

Publication date: Available online 19 February 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Panagiotis Dragonas, Linda M. Kaste, Martha Nunn, Praveen K. Gajendrareddy, Kathleen M. Weber, Mardge Cohen, Oluwatoyin M. Adeyemi, Audrey L. French, Herve Y. Sroussi
AimTo test a hypothesized positive association between low Vitamin D (VitD) serum levels and the severity of periodontal disease in HIV-infected women.Materials and MethodsThis is a cross sectional secondary analysis of data from an oral substudy conducted within the Chicago site of the Women's Interagency HIV Study. Serum VitD levels and clinical attachment loss measurements were available for 74 HIV-infected women. VitD levels were treated as both continuous and categorical variables in bivariate and multivariate analyses. Mean clinical attachment loss (mCAL) was determined for each subject by averaging measurements taken at 4 sites in each measured tooth.ResultsAverage age of study participants (n=74) was 39.6 years (SD 7.2) and the majority were African-American (70.3%) and VitD deficient (58.1%). VitD deficiency was positively associated with higher mCAL (p=.012). With adjustment for race, age, smoking, HIV viral load, an association was found between VitD deficiency and mCAL (Beta 0.438, p=0.036).ConclusionsWe identified a previously unreported association between VitD deficiency and mCAL in HIV-infected women. Larger and more inclusive multisite longitudinal studies are warranted to investigate whether these findings generalize to all HIV infected individuals in the current treatment era and to determine causality.



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