Πέμπτη 22 Φεβρουαρίου 2018

The impact of chemotherapeutic treatment on the oral microbiota of cancer patients: A systematic review

Publication date: Available online 21 February 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Kelly Rocio Vargas Villafuerte, Cristhiam de Jesus Hernandez Martinez, Felipe Torres Dantas, Helio Humberto Angotti Carrara, Francisco José Candido dos Reis, Daniela Bazan Palioto
ObjectiveChemotherapy is a type of systemic treatment that inhibitsneoplastic cells (cancer), producing immunosuppression, and may lead to changes in the oral mucosa and, consequently, in the oral microbiota. The aim of this systematic review was to analyze, in the scientific literature, evidence of the impact of chemotherapy on the oral microbiota.MethodsThe authors conducted a search in the electronic databases PubMed/MEDLINE, Scientific Electronic Library Online (SciELO), LILACS, ScienceDirect, Web of Science, and Cochrane Library for studies that discuss the change of oral microbiota in cancer patients during chemotherapy. Articles published in English were included until July 2017. The quality of the study was assessed using the Ottawa-Newcastle scale.ResultsOf 5252 papers potentially relevant to this review, 17 studies were included in this study. Of these studies, 16 studies used culture techniques and one of them used genetic sequencing. The most frequently observed bacteria were aerobic gram-negative (Klebsiella spp, E. coli, Enterobacter, Pseudomonas spp), anaerobic gram-negative (Veillonella spp, Capnocytophaga), and gram-positive bacteria (Streptococcus spp, Staphylococcus spp).ConclusionsPatients with cancer during chemotherapy present a more complex oral microbiota under favorable conditions for their development during immunosuppression, and these may be responsible for different serious local or systemic pathologies.



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