Subclinical changes in MRI-determined right ventricular volumes and function in subjects with prediabetes and diabetes

Abstract

Objectives

The aim of this study was to assess subclinical changes in right ventricular volumes and function in subjects with prediabetes and diabetes and controls without a history of cardiovascular disease.

Methods

Data from 400 participants in the KORA FF4 study without self-reported cardiovascular disease who underwent 3-T whole-body MRI were obtained. The right ventricle was evaluated using the short axis and a four-chamber view. Diabetes was defined according to WHO criteria. Associations between glucose tolerance and right ventricular parameters were assessed using multivariable adjusted linear regression models.

Results

Data from 337 participants were available for analysis. Of these, 43 (13%) had diabetes, 87 (26%) had prediabetes, and 207 (61%) were normoglycaemic controls. There was a stepwise decrease in right ventricular volumes in men with prediabetes and diabetes in comparison with controls, including right ventricular end-diastolic volume (β = −20.4 and β = −25.6, respectively; p ≤ 0.005), right ventricular end-systolic volume (β = −12.3 and β = −12.7, respectively; p ≤ 0.037) and right ventricular stroke volume (β = −8.1 and β = −13.1, respectively, p ≤ 0.016). We did not observe any association between prediabetes or diabetes and right ventricular volumes in women or between prediabetes or diabetes and right ventricular ejection fraction in men and women.

Conclusions

This study points towards early subclinical changes in right ventricular volumes in men with diabetes and prediabetes.

Key Points

• MRI was used to detect subclinical changes in right ventricular parameters.

• Diabetes mellitus is associated with right ventricular dysfunction.

• Impairment of right ventricular volumes seems to occur predominantly in men.

from Imaging via alkiviadis.1961 on Inoreader http://ift.tt/2EOQtG5