Prevalence of primary open-angle glaucoma among patients with obstructive sleep apnea

Publication date: Available online 31 January 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Arthur H. Friedlander, Lindsay L. Graves, Tina I. Chang, K. Karl Kawakami, Urie K. Lee, Shannon C. Grabich, Zhuang T. Fang, Michelle R. Zeidler, JoAnn A. Giaconi
ObjectiveDetermine primary open angle glaucoma (POAG) prevalence among obstructive sleep apnea (OSA) patients because perioperative environment risks further damaging the optic nerve.Study designAnalyzed "convenience sample" referred by Sleep Medicine for oral appliances because of continuous positive pressure (CPAP) intolerance. Determined aggregate prevalence of the 3 POAG subtypes: ("classic" open angle glaucoma (COAG), normal tension glaucoma (NTG), open angle glaucoma suspect (OAGS); among the index population and compared it to that of same hospital's general population. Similarly determined were associations between OSA severity levels (apnea-hypopnea index; AHI) and POAG subtypes.ResultsAmong the study sample of 225 patients with OSA (96.4% male; mean age 58.5 ± 12.3 years), 47 (20.9%) had POAG; with subtype distribution: (COAG: 12(25.5%), NTG: 8 (17.0%), OAGS: 27 (57.4%)). The POAG prevalence rate among medical center's general population was 2.5% which was significantly less (P < .00001) than among those with comorbid OSA. Severity of the breathing disorder (AHI) failed to demonstrate a significant correlation to any POAG subtype (P > .05).ConclusionThe significant prevalence of POAG among OSA sufferers, suggests need for preoperative consultations from an ophthalmologist to determine eye health and possibly an anesthesiologist to avoid potential vision loss.



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