IJMS, Vol. 19, Pages 570: Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer

IJMS, Vol. 19, Pages 570: Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer

International Journal of Molecular Sciences doi: 10.3390/ijms19020570

Authors: Mariangela Morlando Alessandro Fatica

Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer. By interacting with epigenetic regulators and by controlling chromatin topology, their misregulation may result in an aberrant regulation of gene expression that may contribute to tumorigenesis. Here, we review the functional role and mechanisms of action of lncRNAs implicated in the aberrant epigenetic regulation that has characterized cancer development and progression.

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