IJMS, Vol. 19, Pages 546: The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor

IJMS, Vol. 19, Pages 546: The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor

International Journal of Molecular Sciences doi: 10.3390/ijms19020546

Authors: Rene Baudrand Anand Vaidya

A substantial proportion of patients with hypertension have a low or suppressed renin. This phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic syndromes, acquired somatic mutations, or environmental exposures. Activation of the mineralocorticoid receptor is a common final mechanism for the development of LRH. Classically, the individual causes of LRH have been considered to be rare diseases; however, recent advances suggest that there are milder and “non-classical” variants of many LRH-inducing conditions. In this regard, our understanding of the underlying genetics and mechanisms accounting for LRH, and therefore, potentially the pathogenesis of a large subset of essential hypertension, is evolving. This review will discuss the potential causes of LRH, with a focus on implicated genetic mechanisms, the expanding recognition of non-classical variants of conditions that induce LRH, and the role of the mineralocorticoid receptor in determining this phenotype.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2EUjOPm
via IFTTT