IJMS, Vol. 19, Pages 459: Epigenetics and MicroRNAs in Cancer

IJMS, Vol. 19, Pages 459: Epigenetics and MicroRNAs in Cancer

International Journal of Molecular Sciences doi: 10.3390/ijms19020459

Authors: Alice Ramassone Sara Pagotto Angelo Veronese Rosa Visone

The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional structure of the genome is exploited by cancer cells to promote tumorigenesis. This reprogramming occurs because of hereditable chromatin chemical modifications and the consequent formation of RNA-protein-DNA complexes that represent the principal actors of the epigenetic phenomena. In this regard, the deregulation of a transcribed non-coding RNA may be both cause and consequence of a cancer-related epigenetic alteration. This review summarizes recent findings that implicate microRNAs in the aberrant epigenetic regulation of cancer cells.

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