Patients with primary restless legs syndrome have higher prevalence of autonomic dysfunction and irritable bowel syndrome.

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Patients with primary restless legs syndrome have higher prevalence of autonomic dysfunction and irritable bowel syndrome.

Singapore Med J. 2018 Jan 26;:

Authors: Acar BA, Acar MAG, Acar T, Varım C, Alagöz AN, Demiryürek EB, Doğan Güngen B, Güzey Aras Y

Abstract
INTRODUCTION: Given the limited data on autonomic dysfunction in patients with primary restless legs syndrome (pRLS), we compared the autonomic dysfunction and presence of irritable bowel syndrome (IBS) among patients with pRLS with those among control patients.
METHODS: Consecutive adult drug-naïve patients with pRLS, and age- and gender-matched healthy control patients were enrolled in this study. Diagnoses, based on validated self-reported questionnaires, were made using the following guidelines: the Rome III Classification System for Functional Gastrointestinal Disorders for IBS; the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) for the presence of anxiety and depression, respectively; the Pittsburgh Sleep Quality Index (PSQI) for severity of sleep disturbances; and Scales for Outcomes in Parkinson's disease-Autonomic (SCOPA-AUT) for autonomic dysfunction.
RESULTS: There were 88 patients with pRLS (18 men, 70 women) and 128 control patients (40 men, 88 women). Mean age of patients with pRLS and control patients was 50.3 ± 9.3 years and 49.7 ± 8.2 years, respectively. Overall, 41 (46.6%) of patients with pRLS and 16 (12.5%) of control patients had IBS. Among patients with pRLS, IBS was significantly more common and the total autonomic SCOPA-AUT scores were higher than those found among control patients. Among pRLS patients with IBS, total autonomic SCOPA-AUT, PSQI, BAI and BDI scores were significantly higher than among pRLS patients without IBS. Presence of IBS did not affect the severity of restless legs syndrome.
CONCLUSION: The presence of autonomic nervous system impairment in patients with pRLS, and the strong link between IBS and pRLS merit further, more extensive investigation.

PMID: 29372261 [PubMed - as supplied by publisher]

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