Das AMDP-System wurde unter anderem basierend auf Konzepten der Schizophrenie in den 1960er- und 1970er-Jahren im europäischen Sprachbereich entwickelt. Entsprechend der damaligen Klassifikation wurden Symptome zusammengestellt und in einem Glossar definiert. In der Folgezeit fand das AMDP-System, besonders in Studien zu schizophrenen Patienten, aber auch in der klinischen Praxis, große Anwendung. Die im AMDP-System enthaltenen Symptome und Syndrome erlauben eine differenzierte Abbildung der schizophrenen Symptomatik.
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