Bone marrow oedema predicts bone collapse in paediatric and adolescent leukaemia patients with corticosteroid-induced osteonecrosis

Abstract

Objectives

Corticosteroid treatment of paediatric leukaemia patients can lead to osteonecrosis (ON). We determined whether bone marrow oedema (BME) is an early sign of progressive ON and eventual bone collapse.

Methods

In a retrospective study, two radiologists reviewed MR imaging characteristics of 47 early stage epiphyseal ON in 15 paediatric and adolescent leukaemia patients. Associations between BME on initial imaging studies and subchondral fracture, disease progression and bone collapse were assessed by Cochran-Mantel-Haenszel tests. Differences in time to progression and bone collapse between lesions with and without oedema were assessed by log rank tests.

Results

Forty-seven occurrences of ON were located in weight bearing joints, with 77% occurring in the femur. Seventeen lesions progressed to collapse, two lesions worsened without collapse, and 28 remained stable or improved. BME was significantly associated with subchondral fracture (p = 0.0014), disease progression (p = 0.0015), and bone collapse (p < 0.001), with a sensitivity and specificity of 94% and 77%, respectively, for bone collapse. Time to progression for ON with oedema was 2.7 years (95% CI: 1.7-3.4); while the majority of no-oedema ON were stable (p = 0.0011).

Conclusions

BME is an early sign of progressive ON and eventual bone collapse in paediatric and adolescent leukaemia patients.

Key points

• Bone marrow oedema in corticosteroid-induced osteonecrosis predicts progression to bone collapse.

• Bone marrow oedema is associated with subchondral fractures in corticosteroid-induced osteonecrosis.

• Bone marrow oedema can be used to stratify patients to joint-preserving interventions.

• Absence of bone marrow oedema can justify a "wait and watch" approach.

from Imaging via alkiviadis.1961 on Inoreader http://ift.tt/2jUCDrJ