Optimization of affinity and microsomal stability led to identification of the potent, metabolically stable fenobam analog 4l. Robust in vivo efficacy of 4l was demonstrated in four different models of anxiety. Additionally, a ligand based pharmacophore alignment of fenobam and MPEP is proposed.
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Background Moyamoya angiopathy (MMA) is characterised by a progressive stenosis of the terminal part of the internal carotid arteries and th...
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Abstract The core mission of the Early Stage Professionals in Molecular Imaging Sciences (ESPMIS) Interest Group is to help young scientist...
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Publication date: January 2017 Source: International Journal of Biological Macromolecules, Volume 94, Part A Author(s): Vinicius Jose Silv...
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Communicating with patients at the end of life is regarded as a difficult task, and speaking openly about death is often avoided.1,2 Around ...
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A. M. Y. Yong, SS Yang, KB Tan, SA Ho Indian Dermatology Online Journal 2017 8(3):192-194 The Trichosporon species are yeast-like opport...
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Mucoepidermoid carcinoma is the most common malignant, locally invasive tumour of the salivary glands and accounts for approximately 35% of ...
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IJERPH, Vol. 15, Pages 15: Child Nutritional Status in the Changing Socioeconomic Region of the Northern Amazon, Brazil International Journ...
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