Setting Up the Perimeter of Tolerance: Insights into mTEC Physiology

Publication date: Available online 24 November 2017
Source:Trends in Immunology
Author(s): Pedro M. Rodrigues, Pärt Peterson, Nuno L. Alves
Medullary thymic epithelial cells (mTECs) play a central role in T cell tolerance. However, how the mTEC compartment is maintained remains elusive. We review recent discoveries on new transcription factors involved in mTEC homeostasis and discuss the possibility that their actions might be facilitated by the unique biology of mTECs.



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