This review describes the pathophysiological basis for using procalcitonin to help diagnose infections, and the strengths and weaknesses of implementing the test rationally in a routine clinical setting. Meta-analyses of observational studies and intervention studies both suggest that as a surrogate marker, procalcitonin allows an improved diagnostic assessment of a variety of infections, e.g., respiratory tract infections, meningitis, acute infectious endocarditis and pancreatitis. Measuring procalcitonin is not a substitute for careful clinical assessment and obtaining appropriate cultures in all patients. However, used appropriately, procalcitonin allows an earlier diagnosis of infection and can inform physicians about the course and prognosis of the disease better than more commonly used clinical and laboratory markers. With use of a sensitive assay, a procalcitonin-based therapeutic strategy can safely and markedly reduce antibiotic usage in those respiratory tract infections that are mostly viral, and in viral meningitis. More sensitive procalcitonin assays, with a functional sensitivity within the normal reference range of >0.03 microg/L, should be available soon. There is a need for more intervention studies in other sites of infection to tackle the existing vicious cycle of antibiotic overuse and emerging multiresistance. Furthermore, as procalcitonin is a hormokine mediator, its immunoneutralisation might open new treatment options for sepsis.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2zrVPn0
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
-
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182, Butyric Acid from Probiotic Staphyloco...
-
Does CBD Oil Lower Blood Pressure? This article was originally published at SundayScaries." Madeline Taylor POSTED ON January 13, 20...
-
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης A Novel Technique for Endoscopic Repair of Large Anterior Skull Base Defect...
-
2016-11-22T07-55-59Z Source: International Journal of Medical Science and Public Health Banothu Srinivas, Madhu Mohan Reddy B. Backgrou...
-
2016-10-15T06-30-01Z Source: The Southeast Asian Journal of Case Report and Review Sangita Deepak Kamath, Neeraj Jain, Saurabh Pathak, Ba...
-
BACKGROUND AND PURPOSE: Lesion load is a common biomarker in multiple sclerosis, yet it has historically shown modest association with cl...
-
Abstract The development of focused ion beam-scanning electron microscopy (FIB-SEM) techniques has allowed high-resolution 3D imaging of n...
-
Vol.48 No.2 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1S2Z7n2 via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου