Hyperbaric oxygen treatment did not significantly affect radiation injury in the mandibular area of rats.

Publication date: Available online 2 November 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Tonje Sønstevold, Anne Christine Johannessen, Rolf K. Reed, Gerd S. Salvesen, Linda Stuhr
ObjectiveHyperbaric oxygen therapy (HBOT) has been used to enhance the microcirculation and thereby the oxygen tension in tissues. The present study aimed to investigate the effect of HBOT on radiation injury in the mandibular area of rats.Study designThe left mandible of rats were irradiated by external radiotherapy (15 Gy every other week for a total of 75Gy). Four HBOT strategies were used; two prophylactic groups receiving HBOT either between each radiation treatment or immediately following terminated radiation treatment, and two therapeutic groups receiving HBOT after the latent period of 6 weeks post irradiation either every day (standard HBOT protocol) or three days a week for 6 weeks. Tissue samples of the irradiated area were taken from skin, salivary gland and mandible. All tissues were H&E stained for morphological examination. Furthermore, the skin samples were stained with CD31 for blood vessel analysis.Results.There was no change in blood vessel density, or morphology between controls or HBOT tissues post radiation. Two of 5 HBOT rats had either normalization of dentin or the dentin was not affected by irradiation.Conclusions.HBOT did not affect radiation injury of the mandibular area in rats within 12 weeks post irradiation.



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