Opioid K receptor variant is associated with a delayed onset of dyskinesias in Parkinsons disease

Risk factors for levodopa-induced dyskinesias (LIDs) in Parkinson’s disease (PD) include young age at onset, disease progression and individual dose of levodopa.1 Nevertheless, established risk factors do not fully explain the marked individual variability in the time elapsing between levodopa initiation and the onset of LIDs, and genetic predisposition is likely to play a critical role. To identify the genetic determinants modulating the time at onset of LIDs, we investigated 10 polymorphisms previously associated with LIDs in PD. Among these variants, we selected those additionally associated with addictive disorders, based on the recent hypothesis that pathophysiological mechanisms underlying LIDs share similarities with non-motor hyper-dopaminergic states, such as addictive disorders (including impulse control disorders).2

Clinical records of consecutive outpatients diagnosed with PD, attending our clinic from April 2009 to April 2011 and contributing to the ‘Parkinson Institute Biobank’, were retrospectively reviewed. We included only patients who were free of LIDs...

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