Τρίτη 25 Ιουλίου 2017

G9a coordinates with the RPA complex to promote DNA damage repair and cell survival [Biochemistry]

Histone methyltransferase G9a has critical roles in promoting cancer-cell growth and gene suppression, but whether it is also associated with the DNA damage response is rarely studied. Here, we report that loss of G9a impairs DNA damage repair and enhances the sensitivity of cancer cells to radiation and chemotherapeutics. In...

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