Tough chitosan hydrogel based on purified regeneration and alkaline solvent as biomaterials for tissue engineering applications

Publication date: November 2017
Source:International Journal of Biological Macromolecules, Volume 104, Part A
Author(s): Shichao Bi, Zixian Bao, Xiaoyu Bai, Shihao Hu, Xiaojie Cheng, Xiguang Chen
The chitosan based on purified regeneration could be dissolved in 6wt% aqueous NaOH without freeze-thawing cycles and acetylation processing, and such a solution system was effective and different from other dissolving methods Upon heating, a tough hydrogel was constructed from the chitosan (purified regeneration) alkaline solution. The results of XRD, TEM, SEM and rheology analysis proved that chitosan easily aggregated in the solution and formed a nanofibers network to gelate at elevated temperature and concentration. The merely chitosan hydrogel had a uniform network structure and its (5wt%) compressive fracture stress could reach 0.2MPa. Furthermore, the hydrogels exhibited excellent biodegradability, blood compatibility and cellular compatibility. Therefore, the tough chitosan hydrogels may have a wide range of applications in biomedicine.

Graphical abstract

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