Τρίτη 6 Ιουνίου 2017

Mechanistic insight into the nucleus-vacuole ȷunction based on the Vac8p-Nvȷ1p crystal structure [Biochemistry]

Formation of the nucleus–vacuole junction (NVJ) is mediated by direct interaction between the vacuolar protein Vac8p and the outer nuclear endoplasmic reticulum membrane protein Nvj1p. Herein we report the crystal structure of Vac8p bound to Nvj1p at 2.4-Å resolution. Vac8p comprises a flexibly connected N-terminal H1 helix followed by 12...

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