Abstract
Background
Keloids and hypertrophic scars are benign growths of dermal collagen that can cause physical and psychological (cosmetic) problems for patients. Many modalities of treatment have been advocated for the treatment of keloids, without convincing results.
Methods
A randomised controlled trial was conducted in the Department of Surgery at Silchar Medical College and Hospital, Silchar, Assam for the period from January 2015 to June 2016. Keloids or hypertrophic scars (1cm to 5cm in size) having no history of treatment for the scars in preceding 6 months were included. The subjects were divided into two groups: Group A received intralesional triamcinolone acetonide alone and Group B received triamcinolone acetonide + 5 flourouracil. Eight injections were given at weekly interval. Scars were assessed at 4, 8 weeks during and 4 weeks after the completion of treatment on a five-point scale.
Results
50 patients were included in the study and were divided in two equal groups of 25 each. Good to excellent results were seen in 14 (56%) cases in Group A, compared to 20 (80%) in Group B (p value <0.05). Group B lesions showed better improvement than Group A lesions in pruritus, pain, tenderness, restriction of movements and cosmetic problem. Recurrence was seen in 16% and 4% in both groups respectively.
Conclusion
The combination of triamcinolone acetonide and 5 flourouracil is superior to triamcinolone acetonide alone in treatment of keloids and hypertrophied scars.
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