Joining Forces: Bmi1 Inhibition and Cisplatin Curb Squamous Carcinogenesis.

Joining Forces: Bmi1 Inhibition and Cisplatin Curb Squamous Carcinogenesis.

Cell Stem Cell. 2017 May 04;20(5):575-577

Authors: Brown JA, Schober M

Abstract
Head and neck squamous cell carcinomas (HNSCCs) are refractory to therapeutic interventions. Chen et al. (2017) show that mouse and human HNSCCs and their metastases depend on Bmi1-expressing cancer stem cells and AP1 signaling and that simultaneously inhibiting Bmi1 or AP1, combined with Cisplatin, reduces tumor growth effectively in preclinical models.

PMID: 28475877 [PubMed - in process]

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