Integrin α3β1 has been shown to be a novel candidate target for the imaging and specific therapy of non-small-cell lung cancer. We have previously reported on a peptide containing a novel motif of NGXG that specifically binds to the integrin α3 receptor on lung cancer cells using a one-bead one-peptide combinatorial library. In this study, we developed the peptide cNGEGQQc-based therapeutic agent labeling with radionuclide iodine-131 (131I) and evaluated its characteristics including stability, biodistribution, antitumor activity, and safety. The results showed that 131I-cNGEGQQc was stable in serum. Furthermore, the biodistribution of 131I-cNGEGQQc was determined in normal mice and rabbits. In-vivo biodistribution studies showed that radiolabeled peptide in the kidney was significantly higher than that in other organs. Nude mice bearing lung cancer cell xenografts (H1975 and L78) were used as an in-vivo model for tumor-inhibition efficacy studies with 131I-cNGEGQQc. The tumor growth decreased significantly in mice receiving 131I-labeled peptide compared with the controls and the effect of 131I-labeled peptide can be blocked by unlabeled cNGEGQQc. Safety studies showed that 131I-cNGEGQQc was relatively safe for animals without significant toxicity. Our data suggest that 131I-cNGEGQQc has potential as a targeted radiotherapeutic agent for non-small-cell lung cancer.
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Publication date: Available online 18 January 2017 Source: Free Radical Biology and Medicine Author(s): Jayne Louise Wilson, Frédéric Boui...
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Publication date: March 2017 Source: Free Radical Biology and Medicine, Volume 104 from #AlexandrosSfakianakis via Alexandros G.Sfak...
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Publication date: July 2017 Source: European Journal of Cancer, Volume 79 Author(s): Simon Pernot, Cecile Badoual, Magali Terme, Florence...
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Introduction. The incompleteness of medical records is a significant problem that affects the quality of health care services in many hospit...
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Abstract Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenetic disorder that is caused by mutations in the genes PK...
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Inflammation is an important component of diabetic retinal damage. We previously reported that a novel β-adrenergic receptor agonist, Compou...
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An ambitious plan to save a melting glacier in the Swiss Alps with showers of artificial snow will be tested this summer from #AlexandrosS...
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by Yiquan Wu, Adrian Prager, Simone Boos, Moritz Resch, Ilija Brizic, Michael Mach, Sabrina Wildner, Laura Scrivano, Barbara Adler Herpesv...
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Abstract The aims of this study were to (1) determine if older people at their fast walking speed (FWS) are able to reach the speed require...
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