This paper considers the problem of designing a genetic circuit which is robust to noise effect. To achieve this goal, a mixed and Integral Quadratic Constraints (IQC) approach is proposed. In order to minimize the effects of external noise on the genetic regulatory network in terms of norm, a design procedure of Hill coefficients in the promoters is presented. The IQC approach is introduced to analyze and guarantee the stability of the designed circuit.
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Publication date: January 2018 Source: International Journal of Biological Macromolecules, Volume 106 from #AlexandrosSfakianakis via...
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