Quantitative accuracy of computed tomography perfusion under low-dose conditions, measured using a hollow-fiber phantom

Abstract

Purpose

The purpose of this study was to investigate the quantitative accuracy under low-dose conditions on computed tomography (CT) perfusion using a hollow-fiber phantom that had the theoretical absolute values of perfusion indices.

Materials and methods

Our phantom comprised two components, i.e., a hollow-fiber hemodialyzer to pump the diluted contrast material and a surrounding syringe-shaped X-ray-absorbing body to simulate the absorption of X-rays by a brain and cranium. We performed CTP scans on the phantom under various dose conditions ranging from 20 to 140 mA using a 64-row CT scanner, measuring experimental cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time to peak (TTP) values using a deconvolution algorithm.

Results

The theoretical value of the CBV was within the 95% confidence interval of CBV values measured under 80 mA. The CBV measured under low-dose settings and all CBF values measured were smaller than the theoretically calculated ones, and all MTT values measured were larger. All measured values of the CBV, CBF, MTT, and TTP decreased with an increase in image noise under lower dose conditions.

Conclusion

It is difficult to define a low-dose limit in clinical scan conditions because of the complex characteristics of perfusion indices.

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