Novel autoantibody against the β2-glycoprotein I/HLA-DR complex in patients with refractory cutaneous ulcers

Abstract

Chronic skin ulcers in the lower legs, feet, toes, and digits are sometimes idiopathic and intractable, and occasionally cause limb gangrene. Although there are many conditions that can cause chronic limb ulcers, including primary or secondary vascular diseases, the reasons why specific patients develop chronic skin ulcers have still remained unclear.¹ Antiphospholipid syndrome (APS) is an acquired coagulation disorder occurring as vascular thrombosis or pregnancy complications.

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