Morphological features of structural organization of the cerebellum cortex in old age

Abstract

In this scientific work, organometric, histological, immunomorphologic, and morphometric parameters of the cerebral cortex of 219 corpses of people (108 men and 111 women) of young and old age have been studied. A comparative analysis of the parameters of bulb-shaped neurons in these ages revealed a decrease of their height and width. It was found that the distance between nerve-cell bodies of the ganglionic layer increases with age, which is obviously associated with disorganization progression and the death of bulbshaped neurons. An increase in the number of immunopositive astrocytes for the glial fibrillary acidic protein, protide S-100, and vimentin in the granular layer and the molecular layer of the cerebral cortex and decline in the number of immunopositive bulb-shaped neurons for neuron-specific enolase and immunonegative for the S-100 protein and vimentin that can be regarded as a manifestation of neurodegeneration. Using immunohistochemical methods in research allows a more nuanced approach to the issues of morphological assessment of the cerebral cortex of elderly people and makes it possible to obtain more objective and complete information on postnatal morphogenesis.

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