We read with excitement the article titled “Life-threatening NLRC4-associated hyperinflammation successfully treated with Interleukin-18 inhibition” by Canna et al.1 We congratulate the authors for this outstanding diagnostic and therapeutic triumph. This article also represents translation from the bench of a unique protein, the IL-18 binding protein (IL-18BP),2 into a targeted therapy drug that saved the life of this child. IL-18BP was an unexpected discovery and we believe that a short description of its unique features3,4 is useful to scientists and essential to clinicians and therefore should have been included in the publication of Canna et al.
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Abstract Determining the cause of unexplained death in all age groups, including infants, is a priority in forensic medicine. The triple r...
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Abstract Layer-by-layer (LbL) dip coating, accompanying with the use of micelle structure, allows hydrophobic molecules to be coated on me...
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Abstract In this paper we present the study of a skull belonging to a young male from the Italian Bronze Age showing three perimortem inju...
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Find out more about the wide range of A Levels and full time courses available at Longley Park Sixth Form College, the only independent Sixt...
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Abstract To measure integral doses in image-guided radiation therapy, we developed an integral condenser dosimeter comprising a disposable...
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Objectives. To assess the association between short-term postoperative cognitive dysfuction (POCD) and inflammtory response in patients unde...
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