The timely editorial in The Lancet (Dec 3, p 2713)1 calls for a broadening of our approaches to dementia research. Treatment and prevention of cerebrovascular diseases appear to be the most obvious examples. Covert cerebrovascular disease can contribute to or trigger neurodegeneration. Alzheimer's and other neurodegenerative diseases are common in the elderly, most of whom do not develop dementia. However, if an individual has a component of vascular disease, which occurs in 80% of patients with Alzheimer's disease, it doubles the chances of developing dementia.
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