Although 5-fluorouracil (5-FU) is known to interfere with the synthesis of ribonucleic acid and deoxyribonucleic acid, the mechanism underlying its therapeutic efficacy in colorectal cancer (CRC) has not been fully elucidated. We aimed to investigate the influence of 5-FU on histone acetylation, a well-established anti-cancer target, to reveal novel pharmacological effects of 5-FU and their significance for CRC therapy. Results demonstrated that 5-FU induces global histone de-acetylation in multiple CRC cell lines.
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Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
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Background Hyperthyroidism is associated with increased thrombotic risk. As contact system activation through formation of neutrophil extrac...
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Publication date: Available online 18 May 2016 Source: Cellular Signalling Author(s): José M. Muñoz-Félix, Cristina Cuesta, Nuria Perretta...
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ACS Nano DOI: 10.1021/acsnano.7b02060 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2r2L7mh via...
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The diffusion and adsorption behaviors of sodium and cesium were investigated in the Callovo-Oxfordian claystones (France) under unsaturated...
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Abstract Ocean acidification increases the amount of dissolved inorganic carbon (DIC) available in seawater which can benefit photosynthes...
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Abstract Over the past decades, an increasing need in renewable resources has progressively appeared. This trend concerns not only fossil f...
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Zeinab Nazeeh Shata, Marwa R Amin, Heba M El-Kady, Mervat W Abu-Nazel Avicenna Journal of Medicine 2017 7(2):54-63 Background: Unlike ot...
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