Response to the Letter to the Editor on : "A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets," Cancer Lett. 2016 Nov 28;382(2):203-214

Thank you for highlighting that the computational discovery of the multi-cancer nature of the COL11A1-based signature, as well as the creation of a corresponding multi-cancer gene list using COL11A1 as a seed, has been published in 2010 by Kim et. [1]. Due to our focus on the pan-cancer gene signature of cancer-associated fibroblasts (CAFs) exclusively in primary cancers [2], we did not discuss multiple studies, including our own studies in ovarian cancer, that have identified almost identical gene signatures in comparisons between cancers of different stages of progression.

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