[Correspondence] Biopsy transcriptome expression profiling: proper validation is key

Philip J O'Connell and colleagues (Sept 3, p 983)1 describe a set of 13 genes they claim has high accuracy for prediction of several chronic allograft damage-related phenotypes in kidney transplants. Because of the large number of genes represented on a microarray chip, rigorous methods must be employed to avoid overfitting. We are concerned that the validation methods in this paper were performed incorrectly, leading to inflated estimates of predictive accuracies.

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