Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in Atopic Dermatitis

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by disrupted epidermal barrier functions.¹ Stratum corneum (SC) consists of corneocytes and a lipid-rich extracellular matrix, which plays a key role in epidermal permeability barrier (EPB) functions.^2,3 Major lipid constituents of the SC are ceramides (CERs), free fatty acids (FFAs), cholesterol and triglycerides (TGs).^2,3Staphylococcus aureus (S.aureus) colonization is an important trigger of AD.⁴ Comprehensive profiling of SC lipids using S.aureus colonization status, and association between S.aureus colonization and skin lipid composition, has never been documented.

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