Τρίτη 31 Ιανουαρίου 2017

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity [Physiology]

Mitochondrial fusion is thought to be important for supporting cardiac contractility, but is hardly detectable in cultured cardiomyocytes and is difficult to directly evaluate in the heart. We overcame this obstacle through in vivo adenoviral transduction with matrix-targeted photoactivatable GFP and confocal microscopy. Imaging in whole rat hearts indicated mitochondrial...

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